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A diverse array of recombinant, synthetic and natural immunomodulatory preparations for prophylaxis and treatment of various infections are available today. The results of this
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study suggest that Imiquimod ( Aldara )
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5% cream is a useful new treatment option for MC in children, especially in severe cases. Local side-effects included erythema (85%), itching (75%), burning sensations (23%) and pain (11%).
Three children (23%) discontinued treatment because of local side-effects. Two patients (15%) sho a complete remission, and seven (54%) had a partial response, with a remarkable reduction of the MC lesions. The data in the following tables has been retrieved from the Clinical Studies knowledge area of Prous Science Integrity, the drug discovery and development portal,.
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June 2002.Gateways to Clinical Trials is a guide
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to the most recent clinical trials in current literature and congresses. This issue focuses on the following selection of drugs. Some of these substances, such as granulocyte colony-stimulating factor (G-CSF), interferons, Imiquimod ( Aldara ) and bacterial-derived preparations are already licensed for use in patients. Immunomodulatory regimens offer an attractive approach as an adjunct modality for control of microbial diseases in the era of antibiotic resistance. Practical application
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of the advances in molecular biology, bioinformatics, genomic mining and high-throughput peptide synthesis should foster future discovery and development
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of novel immunomodulators contingent upon scientific evidence rather than dictates of discursive empiricism.
Nine of 13 children
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(69%) who completed treatment responded. Experience in treating molluscum contagiosum in children with Imiquimod ( Aldara ) 5% cream.There is a wide variety of topical or surgical treatment options for molluscum contagiosum (MC). We studied the topical efficacy and tolerance of Imiquimod ( Aldara ), a topical immune-response
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modifier, which stimulates
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the production of interferon-alpha and other cytokines in children with MC. Fighting infection using immunomodulatory agents.The last decade has seen the emergence of immunomodulators as promising therapeutic agents
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in infectious diseases. Others including IL-12, various chemokines, synthetic cytosine phosphate-guanosine
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(CpG) oligodeoxynucleotides and glucans are being investigated extensively in clinical and preclinical studies. In an open-label, follow-up trial, Imiquimod ( Aldara ) 5% cream was applied three times a week for 16 weeks
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to 15 children aged 4-11 years with multiple MC.
However, treatment in young or anxious children is difficult, time-consuming and often painful. In three children (23%) with partial remission, the number of mollusca were considerably reduced, thus avoiding surgical treatment. Four children (31%) sho stable or progressive disease. The dosing schedule and length of treatment requires further evaluation. In general, the treatment was well-tolerated, common antibiotics for bladder infections without systemic side-effects. Abacavir
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sulfate, abarelix, abciximab, alicaforsen sodium, almotriptan, alteplase, amlodipine, amoxicillin trihydrate, amprenavir, argatroban monohydrate, aspirin, atorvastatin calcium, azathioprine; Baclofen, benidipine hydrochloride, benserazide, BMS-214662, bosentan, botulinum toxin type B; Candesartan cilexetil, carbamazepine, carbidopa, carboplatin, ceftriaxone sodium, celecoxib, cetirizine hydrochloride, clarithromycin,
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clavulanate potassium, clopidogrel hydrogensulfate, clozapine, CPI-1189, cyclophosphamide, cytarabine; Darbepoetin alfa, denileukin diftitox, dexamethasone, dipyridamole, droperidol, DW-166HC; Ebastine, efalizumab, efavirenz, eletriptan, enalapril maleate, enfuvirtide, enoxaparin sodium, enrasentan, entacapone, epoetin, eprosartan mesilate, etanercept, etoricoxib; Fenofibratefexofenadine hydrochloride, filgrastim, fludarabine phosphate, fluoxetine hydrochloride fluvoxamine maleate, frovatriptan, furosemide; Gabapentin, galantamine hydrobromide, gatifloxacin, gefitinib, ghrelin (human), glatiramer acetate;
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Haloperidol; Ibuprofen, ibuprofen, guaiacol phebe, idarubicin hydrochloride, imipramine hydrochloride, Imiquimod ( Aldara ), interferon beta, interferon beta-1a, interferon beta-1b, interferon omega, irbesartan, itraconazole; Ketorolac, ketorolac tromethamine; Lamifiban, lamotrigine, lanoteplase, lansoprazole, leflunomide, leuprorelin acetate,
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levetiracetam, levocetirizine, levodopa, lisinopril, loratadine; Manidipine, methylprednisolone, metronidazole, mirtazapine, mizolastine, modafinil, morphine sulfate; Naproxen sodium, naratriptan hydrochloride, nifedipine, NSC-683864; Ofloxacin, olanzapine, omalizumab, omapatrilat, ondansetron hydrochloride, oxcarbazepine; Paclitaxel, parecoxib sodium, paroxetine hydrochloride, phenytoin sodium, pimecrolimus, pramipexole hydrochloride, pravastatin, prednisone, pregabalin; Quetiapine fumarate; Ranitidine hydrochloride, rasburicase, ritonavir, rivastigmine tartrate, rizatriptan benzoate, rofecoxib; Saquinavir mesilate, sertraline, sildenafil citrate, simvastatin, sumatriptan succinate; Tacrolimus, tiagabine hydrochloride, ticlopidine hydrochloride, tirofiban hydrochloride, tolvaptan, topiramate, tretinoin; Valproic antibiotic treatment lyme disease acid, valsartan, venlafaxine hydrochloride, verapamil; Warfarin sodium; Ximelagatran; Zanamivir, ziconotide, zolmitriptan, zonisamide..
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